The Influence of a New Uracil Derivative Carbicyl on Myocardium Bioenergetic Processes

There was carried out research concerning the following metabolic deterioration: the metabolic disorders of nicotinamide nucleotides and such macro-energy compounds as adenyl nucleotides, creatine phosphate and their metabolism enzymes in myocardium tissue in case of anthracycline-induced toxic cardiomyopathy. The results of influence of a new physiologically active compound carbicyl that possesses metabolic effect on bioenergenic processes when used in rats with anthracycline-induced heart failure are presented comparing with other cardiotonic agents of different pharmaceutical classes. This study shows that the administration of a metabolic cardiotonic agent carbicyl to the rats that suffer from adriamycin-induced cardiomyopathy significantly normalizes the state of redox processes in myocardium. Carbicyl normalizes the parameters of mitochondrial function; it decreases the deterioration of energy metabolism in cardiomyocytes; carbicyl increases the content of the oxidized forms of NAD+ and NADH+ coenzymes; and it increases the level of ATP, creatine phosphate and glycogen.